8:00 am
Registration & Breakfast
9:20 am
Opening Remarks
Keynote
9:30 am
Bonnie Bassler
Cross-Domain Quorum Sensing Controls Host-Phage Interactions
Guide Mediated ImmunitySession Chair: Luciano Marraffini
10:10 am
EMBO Young Investigator Lecture: Daan Swarts
Novel insights into prokaryotic Argonaute-mediated immunity
10:40 am
Coffee Break
11:00 am
Jack Bravo
Target selection in Argonaute-mediated anti-plasmid defense
11:30 am
Mert Koka
CRISPR-Csx28 is a nicked tRNA-gated membrane pore activated by Cas13b
11:50 am
Puja Majumder
Mechanistic Diversity of cOA-Activated CARF-membrane Effectors in CRISPR Defense
12:10 pm
Poster Session A & Lunch
Enzymatic Defense ISession Chair: Alex Meeske
2:30 pm
Gierdre Tamulaitiene
Novel enzymatic activity in Thoeris system
3:00 pm
Artem Nemudryi
Bacterial Schlafen proteins mediate phage defense
3:20 pm
Josephine Ramirez & George Lampe
Structural insights into the mechanism of telomerase-like DNA synthesis by an antiviral reverse transcriptase
3:40 pm
Karen Maxwell
Rewiring DNA repair for defence: widespread glycosylases target modified phage genomes
4:10 pm
Coffee Break
Enzymatic Defense IISession Chair: Rafael Pinilla-Redondo
4:30 pm
Hannah Ledvina
Investigating an ancient protein fold: the discovery and characterization of an RNase H-like defense system
5:00 pm
Vindhya Kilaru
A bacterial serine/threonine kinase directly targets a viral protein to prevent phage spread
5:20 pm
Kevin Forsberg
Bacterial and human exonucleases mediate cross-kingdom antiviral immunity
5:40 pm
Close
9:00 am
Breakfast
Featured Speaker
9:30 am
Sylvain Moineau
Phages, Cheese, and Immunity: From Early Clues to a Modern Revolution
Phages Fight BackSession Chair: Joe Bondy-Denomy
10:10 am
Alex Meeske
Phage-encoded transcription factors that silence host CRISPR immunity
10:40 am
Coffee Break
11:00 am
Peter Fineran
Exploitation of defences and counter-defences for high-throughput phage mutagenesis
11:30 am
Hong Li
A phage-encoded anti-CRISPR protein cooperates with host enolase to prevent type III CRISPR immunity
11:50 am
Peter R. Weigele
Phage anti-defense genes encode homologs from well-characterized enzyme families that exhibit previously unknown activities when adapted to hypermodify DNA
12:10 pm
Poster Session B & Lunch
Systems Perspective on Bacterial Immunity ISession Chair: Hannah Ledvina
2:30 pm
Gemma Atkinson
Phage-phage immune systems lurking in diversity hotspots
3:00 pm
Marcel Sprenger
Hidden Amun defensive proteins within defense islands broaden protectivity against phage families
3:20 pm
Marissa N. Feeley
A functional screen identifies novel anti-phage defense systems in Staphylococci
3:40 pm
Aaron Whiteley
Doing the maze backwards: using phage triggers to identify novel defense systems
4:10 pm
Coffee Break
Systems Perspective on Bacterial Immunity IISession Chair: Jack Bravo
4:30 pm
Rafael Pinilla-Redondo
Expanding the Landscape of Retron Systems
5:00 pm
Sukrit Silas
The most important anti-phage defense system in E. coli
5:20 pm
Aude Bernheim & Enzo Poirier
Turning ancestral immunity into immunotherapies
5:50 pm
Close
9:00 am
Breakfast
Signaling in Bacterial ImmunitySession Chair: Naama Aviram
9:40 am
Kim Seed
Activation of parasitic phage satellites in epidemic Vibrio cholerae
10:10 am
Lawrence Abad
Population-level induction of bacterial viral immunity
10:30 am
Coffee Break
11:00 am
Uri Gophna
Diverse responses of an archaeal CBASS
11:30 am
Adam Osinski
TIR-like NADases act in bacterial immunity and the RNA vault
11:50 am
Ali Nabhani
Putting the DisA in PanDA: Diadenylate cyclases in antiphage defense
12:10 pm
Poster Session C & Lunch
Phage Sensing & System Activation ISession Chair: Kim Seed
2:30 pm
Philip Kranzusch
Immunity targets ancient features of viral replication
3:00 pm
Andrea Alexei
Antibacterial toxins are packaged into the capsids of temperate bacteriophages
3:20 pm
Alex Gao
Bacterial pattern recognition of the core phage proteome
3:50 pm
Coffee Break
Phage Sensing & System Activation IISession Chair: Kim Seed
4:10 pm
Maedeh Aghahosseini
Impacts and mechanisms of plasmid-like RNA replication in bacteria
4:30 pm
Alan Davidson
An antiviral STAND system is activated by a short conserved motif in phage DNA polymerases
4:50 pm
Rotem Sorek
Understanding immune signaling in bacteria and beyond
5:20 pm
Close
6:00 pm
Meeting Dinner
Announcement of Poster Awards sponsored by New England Biolabs